Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

Wuqing Huang, Jun Xiao, Jianguang Ji, Liangwan Chen

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

1 Citering (SciVal)

Sammanfattning

Background: Lipid metabolism plays an important role in viral infections. We aimed to assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors and NPC1L1 inhibitior) on COVID-19 outcomes using 2-sample Mendelian Randomization (MR) study.

Methods: We used two kinds of genetic instruments to proxy the exposure of lipid-lowering drugs, including eQTLs of drugs target genes, and genetic variants within or nearby drugs target genes associated with LDL cholesterol from GWAS. Summary-data-based MR (SMR) and inverse-variance weighted MR (IVW-MR) were used to calculate the effect estimates.

Results: SMR analysis found that a higher expression of HMGCR was associated with a higher risk of COVID-19 hospitalization (OR=1.38, 95%CI=1.06-1.81). Similarly, IVW-MR analysis observed a positive association between HMGCR-mediated LDL cholesterol and COVID-19 hospitalization (OR=1.32, 95%CI=1.00-1.74). No consistent evidence from both analyses was found for other associations.

Conclusions: This 2-sample MR study suggested a potential causal relationship between HMGCR inhibition and the reduced risk of COVID-19 hospitalization.

Funding: Fujian Province Major Science and Technology Program.

Originalspråkengelska
Artikelnummere73873
TidskrifteLife
Volym10
Tidigt onlinedatum2021
DOI
StatusPublished - 2021

Bibliografisk information

© 2021, Huang et al.

Ämnesklassifikation (UKÄ)

  • Kardiologi
  • Medicinsk genetik

Fingeravtryck

Utforska forskningsämnen för ”Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här