Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Gustav Smith, Kevin Luk, Christina-Alexandra Schulz, James C Engert, Ron Do, George Hindy, Gull Rukh, Line Dufresne, Peter Almgren, David S Owens, Tamara B Harris, Gina M Peloso, Kathleen F Kerr, Quenna Wong, Albert V Smith, Matthew J Budoff, Jerome I Rotter, L Adrienne Cupples, Stephen Rich, Sekar KathiresanMarju Orho-Melander, Vilmundur Gudnason, Christopher J O'Donnell, Wendy S Post, George Thanassoulis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

139 Citeringar (SciVal)

Sammanfattning

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.
Originalspråkengelska
Sidor (från-till)1764-1771
TidskriftJAMA: The Journal of the American Medical Association
Volym312
Utgåva17
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes

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