Forskningsoutput per år
Forskningsoutput per år
Yanni Li, Kristina Sundquist, Xiao Wang, Naiqi Zhang, Anna Hedelius, Jan Sundquist, Ashfaque A Memon
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Changes in mitochondrial DNA copy number (mtDNA-CN) and telomere length have, separately, been proposed as risk factors for various cancer types. However, those results are conflicting. Here, mtDNA-CN and relative telomere length were measured in 3225 middle-aged women included in a large population-based prospective cohort. The baseline mtDNA-CN in patients with prevalent breast cancer was significantly higher (12.39 copies/µL) than cancer-free individuals. During an average of 15.2 years of follow-up, 520 patients were diagnosed with cancer. Lower mtDNA-CN was associated with decreased risk of genital organ cancer (hazard ratio (HR), 0.84), and shorter telomere length was associated with increased risk of urinary system cancer (HR, 1.79). Furthermore, mtDNA-CN was inversely associated with all-cause (HR, 1.20) and cancer-specific mortality (HR, 1.21) when considering all cancer types. Surprisingly, shorter telomere length was associated with decreased risk of cancer-specific mortality when considering all cancer types (HR, 0.85). Finally, lower mtDNA-CN and shorter telomere length were associated with increased risk of both all-cause and cancer-specific mortality in genital organ cancer patients. In this study population, we found that mtDNA-CN and telomere length were significantly associated with prevalent and incident cancer and cancer mortality. However, these associations were cancer type specific and need further investigation.
Originalspråk | engelska |
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Tidskrift | Cancers |
Volym | 13 |
Nummer | 15 |
DOI | |
Status | Published - 2021 juli 30 |
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)
Memon, A. (PI), Sundquist, K. (PI) & Li, Y. (Forskarstuderande)
2016/05/01 → …
Projekt: Forskning