Asymmetric reduction of ketones with enzymes from acetic acid bacteria

Patrick Adlercreutz

doi:10.1007/BF01041475

Asymmetric reduction of ketones with enzymes from acetic acid bacteria

Patrick Adlercreutz

Bioteknik

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Six strains of acetic acid bacteria were evaluated with respect to their capability to catalyze the stereoselective reduction of ketones. The cells were permeabilized before the bioconversions. The best strains were Gluconobacter oxydans DSM 50049 and Acetobacter aceti DSM 2002. Using either of these two strains it was possible to reduce all 12 ketones to (S)-alcohols with an enantiomeric excess of ≥94 %. The highest level of enzymatic activity was found in Acetobacter aceti DSM 2002.

Originalspråk	engelska
Sidor (från-till)	229-234
Antal sidor	6
Tidskrift	Biotechnology Letters
Volym	13
Nummer	4
DOI	https://doi.org/10.1007/BF01041475
Status	Published - 1991 apr. 1

Ämnesklassifikation (UKÄ)

Biokatalys och enzymteknik

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10.1007/BF01041475

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abstract = "Six strains of acetic acid bacteria were evaluated with respect to their capability to catalyze the stereoselective reduction of ketones. The cells were permeabilized before the bioconversions. The best strains were Gluconobacter oxydans DSM 50049 and Acetobacter aceti DSM 2002. Using either of these two strains it was possible to reduce all 12 ketones to (S)-alcohols with an enantiomeric excess of ≥94 %. The highest level of enzymatic activity was found in Acetobacter aceti DSM 2002.",

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AB - Six strains of acetic acid bacteria were evaluated with respect to their capability to catalyze the stereoselective reduction of ketones. The cells were permeabilized before the bioconversions. The best strains were Gluconobacter oxydans DSM 50049 and Acetobacter aceti DSM 2002. Using either of these two strains it was possible to reduce all 12 ketones to (S)-alcohols with an enantiomeric excess of ≥94 %. The highest level of enzymatic activity was found in Acetobacter aceti DSM 2002.

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Asymmetric reduction of ketones with enzymes from acetic acid bacteria

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Ämnesklassifikation (UKÄ)

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