TY - JOUR
T1 - Autoimmunity in Long Covid and POTS
AU - El-Rhermoul, Fatema-Zahra
AU - Fedorowski, Artur
AU - Eardley, Philip
AU - Taraborrelli, Patricia
AU - Panagopoulos, Dimitrios
AU - Sutton, Richard
AU - Lim, Phang Boon
AU - Dani, Melanie
N1 - © The Author(s) 2023. Published by Oxford University Press.
PY - 2023/6/2
Y1 - 2023/6/2
N2 - Orthostatic intolerance and other autonomic dysfunction syndromes are emerging as distinct symptom clusters in Long Covid. Often accompanying these are common, multi-system constitutional features such as fatigue, malaise and skin rashes which can signify generalized immune dysregulation. At the same time, multiple autoantibodies are identified in both Covid-related autonomic disorders and non-Covid autonomic disorders, implying a possible underlying autoimmune pathology. The lack of specificity of these findings precludes direct interpretations of cause and association, but their prevalence with its supporting evidence is compelling.
AB - Orthostatic intolerance and other autonomic dysfunction syndromes are emerging as distinct symptom clusters in Long Covid. Often accompanying these are common, multi-system constitutional features such as fatigue, malaise and skin rashes which can signify generalized immune dysregulation. At the same time, multiple autoantibodies are identified in both Covid-related autonomic disorders and non-Covid autonomic disorders, implying a possible underlying autoimmune pathology. The lack of specificity of these findings precludes direct interpretations of cause and association, but their prevalence with its supporting evidence is compelling.
U2 - 10.1093/oxfimm/iqad002
DO - 10.1093/oxfimm/iqad002
M3 - Review article
C2 - 37255928
SN - 2633-6960
VL - 4
SP - 1
EP - 9
JO - Oxford Open Immunology
JF - Oxford Open Immunology
IS - 1
M1 - iqad002
ER -