Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review


We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alexa Fluor 647 and TAMRA fluorophores and coupling to a surface plasmon resonance chip for interaction studies with the hepatocyte growth factor known to interact with the GAG heparan sulfate.

Sidor (från-till)2507-2515
TidskriftBioconjugate Chemistry
Tidigt onlinedatum2021
StatusPublished - 2021

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi
  • Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)


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