Benzochromenes from the roots of Bourreria pulchra

Gilda J. Erosa-Rejon; Alejandro Yam-Puc; Manuel J. Chan-Bacab; Alberto Gimenez-Turbax; Efrain Salamanca; Luis M. Pena-Rodriguez; Olov Sterner

doi:10.1016/j.phytol.2009.10.002

Benzochromenes from the roots of Bourreria pulchra

Gilda J. Erosa-Rejon, Alejandro Yam-Puc, Manuel J. Chan-Bacab, Alberto Gimenez-Turbax, Efrain Salamanca, Luis M. Pena-Rodriguez, Olov Sterner

Centrum för analys och syntes

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Originalspråk	engelska
Sidor (från-till)	9-12
Tidskrift	Phytochemistry Letters
Volym	3
Nummer	1
DOI	https://doi.org/10.1016/j.phytol.2009.10.002
Status	Published - 2010

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Ämnesklassifikation (UKÄ)

Organisk kemi

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10.1016/j.phytol.2009.10.002

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@article{c5789915979640da9c59f03b9e263aa5,

title = "Benzochromenes from the roots of Bourreria pulchra",

abstract = "Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.",

keywords = "Bourreria pulchra, Boraginaceae, Benzochromene, Antiprotozoal, Leishmania mexicana, Trypanosoma cruzi",

author = "Erosa-Rejon, {Gilda J.} and Alejandro Yam-Puc and Chan-Bacab, {Manuel J.} and Alberto Gimenez-Turbax and Efrain Salamanca and Pena-Rodriguez, {Luis M.} and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

year = "2010",

doi = "10.1016/j.phytol.2009.10.002",

language = "English",

volume = "3",

pages = "9--12",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Benzochromenes from the roots of Bourreria pulchra

AU - Erosa-Rejon, Gilda J.

AU - Yam-Puc, Alejandro

AU - Chan-Bacab, Manuel J.

AU - Gimenez-Turbax, Alberto

AU - Salamanca, Efrain

AU - Pena-Rodriguez, Luis M.

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2010

Y1 - 2010

N2 - Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

AB - Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

KW - Bourreria pulchra

KW - Boraginaceae

KW - Benzochromene

KW - Antiprotozoal

KW - Leishmania mexicana

KW - Trypanosoma cruzi

U2 - 10.1016/j.phytol.2009.10.002

DO - 10.1016/j.phytol.2009.10.002

M3 - Article

SN - 1874-3900

VL - 3

SP - 9

EP - 12

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 1

ER -

Benzochromenes from the roots of Bourreria pulchra

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