Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.

Fredrik Ejserholm, John Stegmayr, Patrik Bauer, Fredrik Johansson, Lars Wallman, Martin Bengtsson, Stina Oredsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

25 Citeringar (SciVal)
324 Nedladdningar (Pure)

Sammanfattning

The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a flexible neural probe should be more biocompatible than a stiff probe, an OSTE+ probe should be more biocompatible than one composed of a more rigid material. We have investigated the toxicity of OSTE+ as well as of OSTE+ that had been incubated in water for a week (OSTE+H2O) using MTT assays with mouse L929 fibroblasts. We found that OSTE+ showed cytotoxicity, but OSTE+H2O did not. Extracts were analyzed using LC-MS and GC-MS in order to identify leaked chemicals.
Originalspråkengelska
Sidor (från-till)1-10
TidskriftBiomaterials research
Volym19
Nummer19
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

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