Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression

Chiara Ripamonti, Thomas Leitner, Anna Laurén, Ingrid Karlsson, Angela Pastore, Mariangela Cavarelli, Liselotte Antonsson, Anna Plebani, Eva Maria Fenyö, Gabriella Scarlatti

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the R5 phenotype, their viruses showed important biological differences. In the fast progressor there was a higher RANTES sensitivity of the early virus, an increased trend to change the mode of CCR5 receptor use, and a larger genetic evolution. Both children developed an autologous neutralizing antibody response starting from the second year with evidence of the continuous emergence of resistant variants. A marked viral genetic and phenotypic evolution was documented in the fast progressor sibling, which is accompanied by a high viral RANTES sensitivity and persistent neutralizing antibodies.
Originalspråkengelska
Sidor (från-till)1531-1540
TidskriftAIDS Research and Human Retroviruses
Volym23
Nummer12
DOI
StatusPublished - 2007

Ämnesklassifikation (UKÄ)

  • Farmakologi och toxikologi
  • Medicinska grundvetenskaper
  • Mikrobiologi inom det medicinska området

Fingeravtryck

Utforska forskningsämnen för ”Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här