TY - JOUR
T1 - Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
AU - Matsumoto, Shohei
AU - Friberg, Hans
AU - Ferrand-Drake, Michel
AU - Wieloch, Tadeusz
PY - 1999/7/1
Y1 - 1999/7/1
N2 - The mitochondrial permeability transition pore is an inducer of cell death. During the reperfusion phase after cerebral ischemia, calcium accumulates in mitochondria, and a burst of free radical formation occurs, conditions that favor the activation of the mitochondrial permeability transition pore. Here the authors demonstrate that a blocker of the mitochondrial permeability transition pore, the nonimmunosuppressive cyclosporin A analogue N-methyl-Val-4-cyclosporin A (10 mg/kg intraperitoneally), administered during reperfusion and at 24 hours of reperfusion, diminishes infarct size in a rat model of transient focal ischemia of 2 hours' duration. The mitochondrial permeability transition pore may be an important target for drugs against stroke.
AB - The mitochondrial permeability transition pore is an inducer of cell death. During the reperfusion phase after cerebral ischemia, calcium accumulates in mitochondria, and a burst of free radical formation occurs, conditions that favor the activation of the mitochondrial permeability transition pore. Here the authors demonstrate that a blocker of the mitochondrial permeability transition pore, the nonimmunosuppressive cyclosporin A analogue N-methyl-Val-4-cyclosporin A (10 mg/kg intraperitoneally), administered during reperfusion and at 24 hours of reperfusion, diminishes infarct size in a rat model of transient focal ischemia of 2 hours' duration. The mitochondrial permeability transition pore may be an important target for drugs against stroke.
KW - Brain
KW - Cyclosporin A
KW - Mitochondria
KW - Mitochondrial permeability transition
KW - N-methyl-Val-4-cyclosporin A (MeValCsA)
KW - Neuronal death
UR - http://www.scopus.com/inward/record.url?scp=0033495895&partnerID=8YFLogxK
U2 - 10.1097/00004647-199907000-00002
DO - 10.1097/00004647-199907000-00002
M3 - Article
C2 - 10413027
AN - SCOPUS:0033495895
SN - 0271-678X
VL - 19
SP - 736
EP - 741
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 7
ER -