Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

H Anderson; L Brandt; A Ericson; Håkan Olsson; Torgil Möller

Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

H Anderson, L Brandt, A Ericson, Håkan Olsson, Torgil Möller

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

Originalspråk	engelska
Sidor (från-till)	145-148
Tidskrift	Vox Sanguinis
Volym	75
Nummer	2
Status	Published - 1998

Ämnesklassifikation (UKÄ)

Cancer och onkologi

FN:s Globala mål

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title = "Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother",

abstract = "BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.",

keywords = "Adult, Blood Transfusion, Case-Control Studies, Cohort Studies, Delivery, Obstetric, Female, Hodgkin Disease, Humans, Incidence, Lymphoma, Non-Hodgkin, Postpartum Hemorrhage, Pregnancy, Risk Factors, Sweden",

author = "H Anderson and L Brandt and A Ericson and H{\aa}kan Olsson and Torgil M{\"o}ller",

year = "1998",

language = "English",

volume = "75",

pages = "145--148",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

AU - Anderson, H

AU - Brandt, L

AU - Ericson, A

AU - Olsson, Håkan

AU - Möller, Torgil

PY - 1998

Y1 - 1998

N2 - BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

AB - BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

KW - Adult

KW - Blood Transfusion

KW - Case-Control Studies

KW - Cohort Studies

KW - Delivery, Obstetric

KW - Female

KW - Hodgkin Disease

KW - Humans

KW - Incidence

KW - Lymphoma, Non-Hodgkin

KW - Postpartum Hemorrhage

KW - Pregnancy

KW - Risk Factors

KW - Sweden

M3 - Article

C2 - 9784669

SN - 0042-9007

VL - 75

SP - 145

EP - 148

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 2

ER -

Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

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