c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.

Matthew J Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh, Mark J Buttner

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review


The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.
Sidor (från-till)749-760
TidskriftNature Reviews. Microbiology
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Utvecklingsbiologi


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