CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

Roya Waldsee, Sajedeh Eftekhari, Hilda Ahnstedt, Leif Johnson, Lars Edvinsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

13 Citeringar (SciVal)
150 Nedladdningar (Pure)

Sammanfattning

Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.
Originalspråkengelska
Artikelnummer90
TidskriftJournal of Neuroinflammation
Volym11
Utgåva1
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Neurologi

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