CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

Roya Waldsee; Sajedeh Eftekhari; Hilda Ahnstedt; Leif Johnson; Lars Edvinsson

doi:10.1186/1742-2094-11-90

CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

Roya Waldsee, Sajedeh Eftekhari, Hilda Ahnstedt, Leif Johnson, Lars Edvinsson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.

Originalspråk	engelska
Artikelnummer	90
Tidskrift	Journal of Neuroinflammation
Volym	11
Utgåva	1
DOI	https://doi.org/10.1186/1742-2094-11-90
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Neurologi

Tillgång till dokument

10.1186/1742-2094-11-90

BMC__Waldsee_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24886705?dopt=Abstract

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title = "CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.",

abstract = "Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.",

author = "Roya Waldsee and Sajedeh Eftekhari and Hilda Ahnstedt and Leif Johnson and Lars Edvinsson",

year = "2014",

doi = "10.1186/1742-2094-11-90",

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volume = "11",

journal = "Journal of Neuroinflammation",

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T1 - CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

AU - Waldsee, Roya

AU - Eftekhari, Sajedeh

AU - Ahnstedt, Hilda

AU - Johnson, Leif

AU - Edvinsson, Lars

PY - 2014

Y1 - 2014

N2 - Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.

AB - Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.

U2 - 10.1186/1742-2094-11-90

DO - 10.1186/1742-2094-11-90

M3 - Article

C2 - 24886705

VL - 11

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

SN - 1742-2094

IS - 1

M1 - 90

ER -

CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

Sammanfattning

Ämnesklassifikation (UKÄ)

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