Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Cristiano Fava, Therese Ohlsson, Marketa Sjögren, Angela Tagetti, Peter Almgren, Gunnar Engström, Peter Nilsson, Bo Hedblad, Pietro Minuz, Olle Melander

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

7 Citeringar (SciVal)

Sammanfattning

A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.
Originalspråkengelska
Sidor (från-till)1424-1428
TidskriftJournal of Hypertension
Volym32
Utgåva7
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Kardiologi

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