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Sammanfattning
OBJECTIVES: Preeclampsia (PE) is a common pregnancy-related disorder associated with cardiovascular long-term disease. Eighty percent are late-onset PE, occurring after 34 gestational weeks, and can present with severe symptoms. Magnitude and reversibility rate of maternal cardiovascular changes after severe late-onset PE have not been characterized. This study therefore evaluated longitudinal dynamics of maternal cardiovascular changes after severe late-onset PE.
STUDY DESIGN: Six previously normotensive women with severe late-onset PE and eight pregnant controls were included. Severe PE was defined as systolic blood pressure (SBP) ≥ 160 mmHg or diastolic blood pressure (DBP) ≥ 110 mmHg and proteinuria with/without evidence of end-organ dysfunction, or SBP ≥ 140 mmHg or DBP ≥ 90 mmHg with/without proteinuria and with evidence of end-organ dysfunction. Cardiovascular function was assessed by magnetic resonance imaging at 1-3 days, one week and six months postpartum.
RESULTS: Left ventricular mass at 1-3 days postpartum was higher after severe late-onset PE (57 g/m2) compared to after normal pregnancy (48 g/m2; p = 0.01). Pulse wave velocity (PWV) decreased between 1 and 3 days and six months postpartum after PE (6.1 to 5.0 m/s; p = 0.028). There was no difference in PWV 1-3 days postpartum after severe PE compared after normal pregnancy (6.1 versus 5.6 m/s; p = 0.175). Blood pressure normalized within six months in all but one patient.
CONCLUSIONS: Cardiac effects after severe late-onset PE were small and transient. This indicates that left ventricular hypertrophy after severe late-onset PE may be a secondary physiologic response to increased peripheral resistance in PE. Vascular mechanisms rather than persistent cardiac hypertrophy postpartum may be the culprit for increased long-term cardiovascular risk after PE.
Originalspråk | engelska |
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Sidor (från-till) | 18-24 |
Tidskrift | Pregnancy Hypertension |
Volym | 19 |
Tidigt onlinedatum | 2019 dec. 18 |
DOI | |
Status | Published - 2020 |
Bibliografisk information
Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.Ämnesklassifikation (UKÄ)
- Reproduktionsmedicin och gynekologi
Fingeravtryck
Utforska forskningsämnen för ”Cardiovascular effects of severe late-onset preeclampsia are reversed within six months postpartum”. Tillsammans bildar de ett unikt fingeravtryck.Projekt
- 1 Avslutade
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Fetal Cardiovascular Magnetic Resonance Imaging - Technical development and clinical utility
Ryd, D. (Forskarstuderande), Hedström, E. (Handledare) & Steding Ehrenborg, K. (Biträdande handledare)
2019/01/01 → 2022/04/20
Projekt: Avhandling