TY - JOUR
T1 - CART in the enteric nervous system.
AU - Ekblad, Eva
PY - 2006
Y1 - 2006
N2 - The expression, distribution, origin, projections, chemical coding and functions of cocaine and amphetamine-regulated transcript (CART) in the gastro-intestinal tract are reviewed. CART is extensively expressed in the enteric nervous system. Except from being a possible modulator of NO induced intestinal relaxation CART does not seem to play any pivotal role in intestinal motility. Accumulating evidence suggest CART to be neuroprotective, involved in survival and maintenance of enteric neurons. CART expression increases in atrophic intestine thus suggesting a role of CART in intestinal adaptation. In rat antral mucosa CART is expressed in gastrin cells indicating a hormonal role of gastric CART.
AB - The expression, distribution, origin, projections, chemical coding and functions of cocaine and amphetamine-regulated transcript (CART) in the gastro-intestinal tract are reviewed. CART is extensively expressed in the enteric nervous system. Except from being a possible modulator of NO induced intestinal relaxation CART does not seem to play any pivotal role in intestinal motility. Accumulating evidence suggest CART to be neuroprotective, involved in survival and maintenance of enteric neurons. CART expression increases in atrophic intestine thus suggesting a role of CART in intestinal adaptation. In rat antral mucosa CART is expressed in gastrin cells indicating a hormonal role of gastric CART.
KW - Enteric neuronal plasticity
KW - Intestinal adaptation
KW - CART
KW - Enteric nervous system
KW - Hirschsprung's disease
U2 - 10.1016/j.peptides.2005.12.015
DO - 10.1016/j.peptides.2005.12.015
M3 - Review article
C2 - 16759747
VL - 27
SP - 2024
EP - 2030
JO - Peptides
JF - Peptides
SN - 1873-5169
IS - 8
ER -