Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.

Hui Geng, Stefan Carlsén, Nandakumar Kutty Selva, Rikard Holmdahl, Anders Aspberg, Åke Oldberg, Ragnar Mattsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

ABSTRACT: INTRODUCTION: Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS: COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent assay. RESULTS: COMP-deficient mice showed a significant early onset and increase in the severity of CIA in the chronic phase, whereas collagen II-antibody titers were similar in COMP-deficient and wild-type controls. COMP antibodies were not found in wild-type mice. Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. CONCLUSIONS: COMP deficiency enhances the early onset and development of chronic arthritis but does not affect collagen II autoimmunity. These findings accentuate the importance of COMP in cartilage stability.
Originalspråkengelska
ArtikelnummerR134
TidskriftArthritis Research and Therapy
Volym10
Nummer6
DOI
StatusPublished - 2008

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Åke Oldberg´s group (013212049), Connective Tissue Biology (013230151), Medical Inflammation Research (013212019)

Ämnesklassifikation (UKÄ)

  • Reumatologi och inflammation

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