TY - JOUR
T1 - Carvone Contact Allergy in Southern Sweden
T2 - A 21-year Retrospective Study
AU - Kroona, Liv
AU - Isaksson, Marléne
AU - Ahlgren, Camilla
AU - Dahlin, Jakob
AU - Bruze, Magnus
AU - Warfvinge, Gunnar
PY - 2018/11/5
Y1 - 2018/11/5
N2 - Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.
AB - Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.
KW - l-carvoneCAS:6485-40-1
KW - patchtest:allergens:contactallergy:orallichenplanus:orallichenoidlesions
KW - spearmint
U2 - 10.2340/00015555-3009
DO - 10.2340/00015555-3009
M3 - Article
C2 - 30085320
AN - SCOPUS:85056285172
SN - 1651-2057
VL - 98
SP - 938
EP - 942
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 10
ER -