Sammanfattning
In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.
Originalspråk | engelska |
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Sidor (från-till) | 74-80 |
Tidskrift | Biochimica et Biophysica Acta |
Volym | 917 |
Nummer | 1 |
DOI | |
Status | Published - 1987 jan. 1 |
Ämnesklassifikation (UKÄ)
- Medicin och hälsovetenskap
- Gastroenterologi