Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.

Elmo Jensen, Claes-Henrik Florén, Åke Nilsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.
Originalspråkengelska
Sidor (från-till)74-80
TidskriftBiochimica et Biophysica Acta
Volym917
Nummer1
DOI
StatusPublished - 1987 jan. 1

Ämnesklassifikation (UKÄ)

  • Medicin och hälsovetenskap
  • Gastroenterologi

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