Cerebral perfusion in the elderly with nocturnal blood pressure fall

Arkadiusz Siennicki-Lantz, Faina Reinprecht, Johan Axelsson, Sölve Elmståhl

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip.
Originalspråkengelska
Sidor (från-till)715-720
TidskriftEuropean Journal of Neurology
Volym14
Nummer7
DOI
StatusPublished - 2007

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neurology, Malmö (013027010), Division of Geriatric Medicine (013040040), Department of Health Sciences (013220000)

Ämnesklassifikation (UKÄ)

  • Hälsovetenskaper
  • Gerontologi, medicinsk/hälsovetenskaplig inriktning
  • Neurologi

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