Characterization and modeling of acousto-optic signal strengths in highly scattering media

Alexander Bengtsson, David Hill, Meng Li, Mengqiao Di, Magnus Cinthio, Tobias Erlöv, Stefan Andersson-Engels, Nina Reistad, Andreas Walther, Lars Rippe, Stefan Kröll

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.

Originalspråkengelska
Sidor (från-till)5565-5584
Antal sidor20
TidskriftBiomedical Optics Express
Volym10
Nummer11
DOI
StatusPublished - 2019

Ämnesklassifikation (UKÄ)

  • Medicinsk laboratorie- och mätteknik
  • Atom- och molekylfysik och optik

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