Clinical Management and Transplant Considerations in Pediatric Pulmonary Hypertension Due to Left Heart Disease: A Scientific Statement From the American Heart Association

Rachel K Hopper, Georg Hansmann, Seth A Hollander, Anne I Dipchand, Oscar van der Have, Colleen Iler, Cynthia Herrington, Erika B Rosenzweig, Juan C Alejos, Karin Tran-Lundmark, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative & Resuscitation; Council on Clinical Cardiology; and Council on Cardiovascular Stroke Nursing

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in pediatrics. The result is heterogeneity with respect to hemodynamic assessment, use of pulmonary vasodilator therapies, and heart transplant listing. This scientific statement aims to synthesize the available data and highlight areas of general consensus as well as important knowledge gaps.

Originalspråkengelska
Artikelnummere000086
TidskriftCirculation. Heart failure
DOI
StatusE-pub ahead of print - 2024 dec. 9

Ämnesklassifikation (UKÄ)

  • Kardiologi

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