Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study

Nima Tanha, Ilja Areskog Lejbman, Liesbet De Bus, Gennaro De Pascale, Jose Garnacho-Montero, Marc Leone, Shigeki Fujitani, Jan J. De Waele, Gustav Torisson, Fredrik Sjövall

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Purpose
In a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.

Materials and methods
Patients from the DIANA study were grouped and analysed by combination versus mono antibiotic therapy. Clinical cure was defined as survival and resolution of all signs and symptoms related to the infection. Odds ratios (ORs) were calculated by logistic regression analyses.

Results
Of the 1398 included patients, 568 patients (41%) received combination therapy. In total, 641(46%) patients achieved clinical cure and 135 (10%) patients had died as of day 7. There were no significant associations between combination and mono therapy relating to clinical cure and mortality.

Conclusions
This study found no differences in clinical cure and mortality between empirical combination versus mono therapy in a large cohort of ICU patients with a suspected infection.
Originalspråkengelska
Artikelnummer154501
Sidor (från-till)1-6
TidskriftJournal of Critical Care
Volym80
DOI
StatusE-pub ahead of print - 2024
Externt publiceradJa

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