TY - JOUR
T1 - Coeliac disease in children with type 1 diabetes
AU - Kurppa, Kalle
AU - Laitinen, Anna
AU - Agardh, Daniel
PY - 2018/2
Y1 - 2018/2
N2 - Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.
AB - Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.
UR - http://www.scopus.com/inward/record.url?scp=85041576654&partnerID=8YFLogxK
U2 - 10.1016/S2352-4642(17)30172-4
DO - 10.1016/S2352-4642(17)30172-4
M3 - Review article
AN - SCOPUS:85041576654
SN - 2352-4642
VL - 2
SP - 133
EP - 143
JO - The Lancet Child and Adolescent Health
JF - The Lancet Child and Adolescent Health
IS - 2
ER -