Congenital and acquired activated protein C resistance.

Gerry A F Nicolaes, Björn Dahlbäck

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

27 Citeringar (SciVal)

Sammanfattning

Resistance to the anticoagulant action of activated protein C, APC resistance, is a highly prevalent risk factor for venous thrombosis among individuals of Caucasian origin. In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FVLeiden), which predicts the replacement of Arg506 with a Gln at one of the cleavage sites for APC in factor V. Factor V is a Janus-faced protein with dual functions, serving as an essential nonenzymatic cofactor in both pro- and anticoagulant pathways. Procoagulant factor Va, generated after proteolysis by thrombin or factor Xa, is a cofactor to factor Xa in the activation of prothrombin, whereas anticoagulant factor V, generated after proteolysis by APC, functions as a cofactor in the APC-mediated degradation of FVIIIa. The FVLeiden mutation affects the anticoagulant response to APC at two distinct levels of the coagulation pathway, as it impairs degradation of both activated factor V and activated factor VIII, the latter effect inasmuch as FVLeiden is a poor APC cofactor. Several other genetic traits, some of them quite common, are known to affect the anticoagulant response to APC, but none of them cause the same severe APC-resistance phenotype as FVLeiden and their importance as risk factors for thrombosis is unclear. A poor APC response may also result from acquired conditions, some of which are clearly involved in the pathogenesis of venous thrombosis. Venous thrombosis is a typical multifactorial disease, the pathogenesis of which involves multiple gene-gene and gene-environment interactions. In many patients with severe thrombophilia, APC resistance is found as a contributing risk factor.
Originalspråkengelska
Sidor (från-till)33-46
TidskriftSeminars in Vascular Medicine
Volym3
Utgåva1
DOI
StatusPublished - 2003

Ämnesklassifikation (UKÄ)

  • Läkemedelskemi

Fingeravtryck

Utforska forskningsämnen för ”Congenital and acquired activated protein C resistance.”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här