Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles

Sandra Sjostrand, Marion Bacou, Adrian Thomson, Katarzyna Kaczmarek, Maria Evertsson, Ingrid Svensson, Susan M. Farrington, Susan Moug, Tomas Jansson, Carmel M. Moran, Helen Mulvana

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review

Sammanfattning

Despite advances in MRI, the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced tissue deformations. The feasibility of the proposed application was explored using a combination of pre-clinical ultrasound imaging and finite element analysis. First, contrast enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, preliminary CE-MMUS data were acquired as a proof of concept. Third, the magneto-mechanical interactions of a magnetic microbubble with an elastic solid were simulated using finite element software. Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occurring 3.7 s post-injection. Preliminary CE-MMUS indicates the presence of magnetic contrast agent in the lymph node. The finite element analysis explores how the magnetic force is transferred to motion of the solid, which depends on elasticity and bubble radius, indicating an inverse relation with displacement. Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Clinical Relevance-Robust detection and characterisation of lymph nodes could be aided by visualising lymphatic drainage of magnetic microbubbles using contrast enhanced ultrasound imaging and magneto-motion, which is dependent on tissue mechanical properties.

Originalspråkengelska
Titel på värdpublikation44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
FörlagIEEE - Institute of Electrical and Electronics Engineers Inc.
Sidor194-197
Antal sidor4
ISBN (elektroniskt)9781728127828
DOI
StatusPublished - 2022
Evenemang44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, Storbritannien
Varaktighet: 2022 juli 112022 juli 15

Publikationsserier

NamnProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volym2022-July
ISSN (tryckt)1557-170X

Konferens

Konferens44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Land/TerritoriumStorbritannien
OrtGlasgow
Period2022/07/112022/07/15

Bibliografisk information

Publisher Copyright:
© 2022 IEEE.

Ämnesklassifikation (UKÄ)

  • Radiologi och bildbehandling

Fingeravtryck

Utforska forskningsämnen för ”Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här