Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging: Assessment of sensitivity and resolution to detect alterations in tissue stiffness

Sandra Sjostrand, Maria Evertsson, Claire Thring, Marion Bacou, Susan Farrington, Susan Moug, Carmel Moran, Tomas Jansson, Helen Mulvana

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review

Sammanfattning

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.

Originalspråkengelska
Titel på värdpublikation2019 IEEE International Ultrasonics Symposium, IUS 2019
FörlagIEEE - Institute of Electrical and Electronics Engineers Inc.
Sidor1077-1080
Antal sidor4
ISBN (elektroniskt)9781728145969
ISBN (tryckt)978-1-7281-4597-6
DOI
StatusPublished - 2019 dec. 9
Evenemang2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, Storbritannien
Varaktighet: 2019 okt. 62019 okt. 9

Publikationsserier

NamnIEEE International Ultrasonics Symposium, IUS
Volym2019-October
ISSN (tryckt)1948-5719
ISSN (elektroniskt)1948-5727

Konferens

Konferens2019 IEEE International Ultrasonics Symposium, IUS 2019
Land/TerritoriumStorbritannien
OrtGlasgow
Period2019/10/062019/10/09

Ämnesklassifikation (UKÄ)

  • Medicinsk laboratorie- och mätteknik

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