Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets

P. Liuba, Sune Johansson, E. Pesonen, Thomas Higgins, A. Forslid, Axel Kornerup-Hansen, V. Perez De Sa

Forskningsoutput: TidskriftsbidragPublicerat konferensabstractPeer review

Sammanfattning

Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery.
Originalspråkengelska
ArtikelnummerP-47
Sidor (från-till)S70
TidskriftCardiology in the Young
Volym21
UtgåvaS1
DOI
StatusPublished - 2011 maj 1
Evenemang45th Annual Meeting of the European Paediatric Cardiology - Granada, Spanien
Varaktighet: 2011 maj 182011 maj 21
Konferensnummer: 45

Ämnesklassifikation (UKÄ)

  • Kardiologi

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