CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Tobias Skillbäck; Bahman Farahmand; Jonathan W Bartlett; Christoffer Rosén; Niklas Mattsson; Katarina Nägga; Lena Kilander; Dorota Religa; Anders Wimo; Bengt Winblad; Lars Rosengren; Jonathan M Schott; Kaj Blennow; Maria Eriksdotter; Henrik Zetterberg

doi:10.1212/WNL.0000000000001015

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Tobias Skillbäck, Bahman Farahmand, Jonathan W Bartlett, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Lars Rosengren, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

Originalspråk	engelska
Sidor (från-till)	1945-1953
Tidskrift	Neurology
Volym	83
Nummer	21
DOI	https://doi.org/10.1212/WNL.0000000000001015
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Neurologi

Tillgång till dokument

10.1212/WNL.0000000000001015

http://www.ncbi.nlm.nih.gov/pubmed/25339208?dopt=Abstract

Citera det här

Skillbäck, T., Farahmand, B., Bartlett, J. W., Rosén, C., Mattsson, N., Nägga, K., Kilander, L., Religa, D., Wimo, A., Winblad, B., Rosengren, L., Schott, J. M., Blennow, K., Eriksdotter, M., & Zetterberg, H. (2014). CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival. Neurology, 83(21), 1945-1953. https://doi.org/10.1212/WNL.0000000000001015

@article{d21cbefced614ca2b371a389a4871afe,

title = "CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.",

abstract = "We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.",

author = "Tobias Skillb{\"a}ck and Bahman Farahmand and Bartlett, {Jonathan W} and Christoffer Ros{\'e}n and Niklas Mattsson and Katarina N{\"a}gga and Lena Kilander and Dorota Religa and Anders Wimo and Bengt Winblad and Lars Rosengren and Schott, {Jonathan M} and Kaj Blennow and Maria Eriksdotter and Henrik Zetterberg",

year = "2014",

doi = "10.1212/WNL.0000000000001015",

language = "English",

volume = "83",

pages = "1945--1953",

journal = "Neurology",

issn = "1526-632X",

publisher = "Lippincott Williams & Wilkins",

number = "21",

}

Skillbäck, T, Farahmand, B, Bartlett, JW, Rosén, C, Mattsson, N, Nägga, K, Kilander, L, Religa, D, Wimo, A, Winblad, B, Rosengren, L, Schott, JM, Blennow, K, Eriksdotter, M & Zetterberg, H 2014, 'CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.', Neurology, vol. 83, nr. 21, s. 1945-1953. https://doi.org/10.1212/WNL.0000000000001015

TY - JOUR

T1 - CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

AU - Skillbäck, Tobias

AU - Farahmand, Bahman

AU - Bartlett, Jonathan W

AU - Rosén, Christoffer

AU - Mattsson, Niklas

AU - Nägga, Katarina

AU - Kilander, Lena

AU - Religa, Dorota

AU - Wimo, Anders

AU - Winblad, Bengt

AU - Rosengren, Lars

AU - Schott, Jonathan M

AU - Blennow, Kaj

AU - Eriksdotter, Maria

AU - Zetterberg, Henrik

PY - 2014

Y1 - 2014

N2 - We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

AB - We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

U2 - 10.1212/WNL.0000000000001015

DO - 10.1212/WNL.0000000000001015

M3 - Article

C2 - 25339208

SN - 1526-632X

VL - 83

SP - 1945

EP - 1953

JO - Neurology

JF - Neurology

IS - 21

ER -

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Sammanfattning

Ämnesklassifikation (UKÄ)

Tillgång till dokument

Fingeravtryck

Citera det här