Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Oliver Kluth, Mandy Stadion, Pascal Gottmann, Heja Aga, Markus Jähnert, Stephan Scherneck, Heike Vogel, Ulrika Krus, Anett Seelig, Charlotte Ling, Jantje Gerdes, Annette Schürmann

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Originalspråkengelska
Sidor (från-till)3027-3036.e3
TidskriftCell Reports
Volym26
Nummer11
DOI
StatusPublished - 2019

Ämnesklassifikation (UKÄ)

  • Medicinsk genetik och genomik (Här ingår: Genterapi)
  • Endokrinologi och diabetes

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