Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Kristina Karrman; Anders Castor; Mikael Behrendtz; Erik Forestier; Linda Olsson; Mats Ehinger; Andrea Biloglav; Thoas Fioretos; Kajsa Paulsson; Bertil Johansson

doi:10.1186/s13045-015-0138-0

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Kristina Karrman, Anders Castor, Mikael Behrendtz, Erik Forestier, Linda Olsson, Mats Ehinger, Andrea Biloglav, Thoas Fioretos, Kajsa Paulsson, Bertil Johansson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

189 Nedladdningar (Pure)

Sammanfattning

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

Originalspråk	engelska
Artikelnummer	42
Tidskrift	Journal of Hematology & Oncology
Volym	8
Nummer	1
DOI	https://doi.org/10.1186/s13045-015-0138-0
Status	Published - 2015

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Clinical Genetics (013022003)

Ämnesklassifikation (UKÄ)

Medicinsk genetik
Pediatrik
Cancer och onkologi

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.1186/s13045-015-0138-0

BMC_Karrman_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25903014?dopt=Abstract

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Citera det här

Karrman, K., Castor, A., Behrendtz, M., Forestier, E., Olsson, L., Ehinger, M., Biloglav, A., Fioretos, T., Paulsson, K., & Johansson, B. (2015). Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. Journal of Hematology & Oncology, 8(1), Artikel 42. https://doi.org/10.1186/s13045-015-0138-0

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title = "Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.",

abstract = "Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.",

author = "Kristina Karrman and Anders Castor and Mikael Behrendtz and Erik Forestier and Linda Olsson and Mats Ehinger and Andrea Biloglav and Thoas Fioretos and Kajsa Paulsson and Bertil Johansson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Clinical Genetics (013022003)",

year = "2015",

doi = "10.1186/s13045-015-0138-0",

language = "English",

volume = "8",

journal = "Journal of Hematology & Oncology",

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publisher = "BioMed Central (BMC)",

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Karrman, K, Castor, A, Behrendtz, M, Forestier, E, Olsson, L , Ehinger, M, Biloglav, A, Fioretos, T , Paulsson, K & Johansson, B 2015, 'Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.', Journal of Hematology & Oncology, vol. 8, nr. 1, 42. https://doi.org/10.1186/s13045-015-0138-0

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. / Karrman, Kristina; Castor, Anders; Behrendtz, Mikael et al.
I: Journal of Hematology & Oncology, Vol. 8, Nr. 1, 42, 2015.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

TY - JOUR

T1 - Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

AU - Karrman, Kristina

AU - Castor, Anders

AU - Behrendtz, Mikael

AU - Forestier, Erik

AU - Olsson, Linda

AU - Ehinger, Mats

AU - Biloglav, Andrea

AU - Fioretos, Thoas

AU - Paulsson, Kajsa

AU - Johansson, Bertil

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Paediatrics (Lund) (013002000), Division of Clinical Genetics (013022003)

PY - 2015

Y1 - 2015

N2 - Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

AB - Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

U2 - 10.1186/s13045-015-0138-0

DO - 10.1186/s13045-015-0138-0

M3 - Article

C2 - 25903014

SN - 1756-8722

VL - 8

JO - Journal of Hematology & Oncology

JF - Journal of Hematology & Oncology

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ER -