Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium

David Grommisch, Menghan Wang, Evelien Eenjes, Maja Svetličič, Qiaolin Deng, Pontus Giselsson, Maria Genander

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Progenitor cells adapt their behavior in response to tissue demands. However, the molecular mechanisms controlling esophageal progenitor decisions remain largely unknown. Here, we demonstrate the presence of a Troy (Tnfrsf19)-expressing progenitor subpopulation localized to defined regions along the mouse esophageal axis. Lineage tracing and mathematical modeling demonstrate that Troy-positive progenitor cells are prone to undergoing symmetrical fate choices and contribute to esophageal tissue homeostasis long term. Functionally, TROY inhibits progenitor proliferation and enables commitment to differentiation without affecting fate symmetry. Whereas Troy expression is stable during esophageal homeostasis, progenitor cells downregulate Troy in response to tissue stress, enabling proliferative expansion of basal cells refractory to differentiation and reestablishment of tissue homeostasis. Our results demonstrate functional, spatially restricted progenitor heterogeneity in the esophageal epithelium and identify how dynamic regulation of Troy coordinates tissue generation.

Originalspråkengelska
Sidor (från-till)1269-1283.e6
TidskriftDevelopmental Cell
Volym59
Nummer10
DOI
StatusPublished - 2024 maj

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi

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