Design and clinical evaluation of robust PID control of propofol anesthesia in children

Klaske van Heusden; Guy A. Dumont; Kristian Soltesz; Christian L. Petersen; Aryannah Umedaly; Nicholas West; J. Mark Ansermino

doi:10.1109/TCST.2013.2260543

Design and clinical evaluation of robust PID control of propofol anesthesia in children

Klaske van Heusden, Guy A. Dumont, Kristian Soltesz, Christian L. Petersen, Aryannah Umedaly, Nicholas West, J. Mark Ansermino

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.

Originalspråk	engelska
Sidor (från-till)	491-501
Tidskrift	IEEE Transactions on Control Systems Technology
Volym	22
Nummer	2
DOI	https://doi.org/10.1109/TCST.2013.2260543
Status	Published - 2014

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SDG 3 – God hälsa och välbefinnande

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10.1109/TCST.2013.2260543

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Link to publication in Scopus

Anesthesia in Closed Loop
Soltesz, K. (PI), Troeng, O. (Forskarstuderande), Bagge Carlson, F. (Forskarstuderande) & Cervin, A. (Forskare)
2011/01/01 → 2020/01/01
Projekt: Forskning
LCCC
Holmqvist, A. (Forskare), Andersson, N. (Forskare), Cervin, A. (Forskare), Mannesson, A. (Forskare), Gattami, A. (Forskare), Ghulchak, A. (Forskare), Papadopoulos, A. V. (Forskare), Rantzer, A. (Forskare), Robertsson, A. (Forskare), Sootla, A. (Forskare), THEORIN, A. (Forskare), Bernhardsson, B. (Forskare), Olofsson, B. (Forskare), Wittenmark, B. (Forskare), Grussler, C. (Forskare), Johnsson, C. (Forskare), MADJIDIAN, D. (Forskare), Johannesson, E. (Forskare), Magnusson, F. (Forskare), Ståhl, F. (Forskare), Como, G. (Forskare), Chasparis, G. (Forskare), Turesson, G. (Forskare), Dressler, I. (Forskare), Åkesson, J. (Forskare), Cho, J. H. (Forskare), Årzén, K.-E. (Forskare), Åström, K. J. (Forskare), Sou, K. C. (Forskare), Mårtensson, K. (Forskare), Berntorp, K. (Forskare), Soltesz, K. (Forskare), Lessard, L. (Forskare), Hast, M. (Forskare), Rönn, M. (Forskare), Ansbjerg Kjær, M. (Forskare), Maggio, M. (Forskare), Kristalny, M. (Forskare), Garpinger, O. (Forskare), From, P. J. (Forskare), Larsson, P.-O. (Forskare), Giselsson, P. (Forskare), Johansson, R. (Forskare), Hägglund, T. (Forskare), Vladimerou, V. (Forskare), Romero Segovia, V. (Forskare), Aurelius, A. (Forskare), Cedersjö, G. (Forskare), Bür, K. (Forskare), Dellkrantz, M. (Forskare), Du, M. (Forskare), Amani, P. (Forskare), Larsson, R. (Forskare), Tärneberg, W. (Forskarstuderande), Li, Z. (Forskare), Yin, L. (Forskare), Tufvesson, F. (Forskare), Höst, S. (Forskare), Nilsson, B. (Forskare), Stenström, S. (Forskare), Andersson, J. A. (Forskare), Diehl, S. (Forskare), Dürango, J. (Forskare), Ghazaei Ardakani, M. (Forskare), Forsberg, P.-O. (Forskare), Bengtsson, F. (Forskare), Jörntell, H. (Forskare), Arévalo, C. (Forskare), Führer, C. (Forskare), Andersson, C. (Forskare), Mohammadi, F. (Forskare), Ödling, P. (Forskare), Andersson, M. (Forskare), Kihl, M. (Forskare) & Tunestål, P. (Forskare)
2008/07/01 → 2018/06/30
Projekt: Forskning

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title = "Design and clinical evaluation of robust PID control of propofol anesthesia in children",

abstract = "This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.",

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author = "\{van Heusden\}, Klaske and Dumont, \{Guy A.\} and Kristian Soltesz and Petersen, \{Christian L.\} and Aryannah Umedaly and Nicholas West and Ansermino, \{J. Mark\}",

year = "2014",

doi = "10.1109/TCST.2013.2260543",

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AU - van Heusden, Klaske

AU - Dumont, Guy A.

AU - Soltesz, Kristian

AU - Petersen, Christian L.

AU - Umedaly, Aryannah

AU - West, Nicholas

AU - Ansermino, J. Mark

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AB - This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.

KW - anesthesia

KW - robust control

KW - clinical trials

KW - PID control

UR - https://www.scopus.com/pages/publications/84897597903

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DO - 10.1109/TCST.2013.2260543

M3 - Article

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JO - IEEE Transactions on Control Systems Technology

JF - IEEE Transactions on Control Systems Technology

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Design and clinical evaluation of robust PID control of propofol anesthesia in children

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Projekt

Anesthesia in Closed Loop

LCCC

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