Determination of 14 Circulating microRNAs in Swedes and Iraqis with and without Diabetes Mellitus Type 2.

Xiao Wang; Jan Sundquist; Bengt Zöller; Ashfaque Memon; Karolina Palmér; Kristina Sundquist; Louise Bennet

doi:10.1371/journal.pone.0086792

Determination of 14 Circulating microRNAs in Swedes and Iraqis with and without Diabetes Mellitus Type 2.

Xiao Wang, Jan Sundquist, Bengt Zöller, Ashfaque Memon, Karolina Palmér, Kristina Sundquist, Louise Bennet

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not been investigated. The aim of this study was to explore the ethnic specific expression (Swedish and Iraqi) of a panel of 14 previously identified miRNAs in patients without T2D (including those with prediabetes) and T2D.

Originalspråk	engelska
Artikelnummer	e86792
Tidskrift	PLoS ONE
Volym	9
Nummer	1
DOI	https://doi.org/10.1371/journal.pone.0086792
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Hälsovetenskap

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.1371/journal.pone.0086792

Plos_Wang_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24497980?dopt=Abstract

The MEDIM project
Bennet, L. (PI)
2008/01/01 → …
Projekt: Forskning

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title = "Determination of 14 Circulating microRNAs in Swedes and Iraqis with and without Diabetes Mellitus Type 2.",

abstract = "Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not been investigated. The aim of this study was to explore the ethnic specific expression (Swedish and Iraqi) of a panel of 14 previously identified miRNAs in patients without T2D (including those with prediabetes) and T2D.",

keywords = "Aged, Biomarkers, case-control studies, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Iraq, Male, MicroRNAs, Middle Aged, Sweden, Urban Population",

author = "Xiao Wang and Jan Sundquist and Bengt Z{\"o}ller and Ashfaque Memon and Karolina Palm{\'e}r and Kristina Sundquist and Louise Bennet",

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AU - Wang, Xiao

AU - Sundquist, Jan

AU - Zöller, Bengt

AU - Memon, Ashfaque

AU - Palmér, Karolina

AU - Sundquist, Kristina

AU - Bennet, Louise

PY - 2014

Y1 - 2014

N2 - Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not been investigated. The aim of this study was to explore the ethnic specific expression (Swedish and Iraqi) of a panel of 14 previously identified miRNAs in patients without T2D (including those with prediabetes) and T2D.

AB - Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not been investigated. The aim of this study was to explore the ethnic specific expression (Swedish and Iraqi) of a panel of 14 previously identified miRNAs in patients without T2D (including those with prediabetes) and T2D.

KW - Aged

KW - Biomarkers

KW - case-control studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Insulin Resistance

KW - Iraq

KW - Male

KW - MicroRNAs

KW - Middle Aged

KW - Sweden

KW - Urban Population

U2 - 10.1371/journal.pone.0086792

DO - 10.1371/journal.pone.0086792

M3 - Article

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e86792

ER -

Determination of 14 Circulating microRNAs in Swedes and Iraqis with and without Diabetes Mellitus Type 2.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

Fingeravtryck

Projekt

The MEDIM project

Citera det här