Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu; K A Krogh; M Granados; Jan Åke Jönsson; B Halling-Sorensen

doi:10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

J Raich-Montiu, K A Krogh, M Granados, Jan Åke Jönsson, B Halling-Sorensen

Centrum för analys och syntes

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

34 Citeringar (SciVal)

Sammanfattning

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

Originalspråk	engelska
Sidor (från-till)	275-280
Tidskrift	Journal of Chromatography A
Volym	1187
Utgåva	1-2
DOI	https://doi.org/10.1016/j.chroma.2008.02.063
Status	Published - 2008

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Ämnesklassifikation (UKÄ)

Analytisk kemi

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10.1016/j.chroma.2008.02.063

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Raich-Montiu, J., Krogh, K. A., Granados, M., Jönsson, J. Å., & Halling-Sorensen, B. (2008). Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography A, 1187(1-2), 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

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title = "Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry",

abstract = "A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.",

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Raich-Montiu, J, Krogh, KA, Granados, M, Jönsson, JÅ & Halling-Sorensen, B 2008, 'Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry', Journal of Chromatography A, vol. 1187, nr. 1-2, s. 275-280. https://doi.org/10.1016/j.chroma.2008.02.063

Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry. / Raich-Montiu, J; Krogh, K A; Granados, M; Jönsson, Jan Åke; Halling-Sorensen, B.

I: Journal of Chromatography A, Vol. 1187, Nr. 1-2, 2008, s. 275-280.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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AU - Krogh, K A

AU - Granados, M

AU - Jönsson, Jan Åke

AU - Halling-Sorensen, B

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AB - A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.

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