Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communication from the SSC of the ISTH

Adrian Minford, Leonardo R. Brandão, Maha Othman, Christoph Male, Rezan Abdul-Kadir, Paul Monagle, Andrew D. Mumford, Dorothy Adcock, Björn Dahlbäck, Predrag Miljic, Maria T. DeSancho, Jun Teruya

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Severe congenital protein C deficiency (SCPCD) is rare and there is currently substantial variation in the management of this condition. A joint project by three Scientific and Standardization Committees of the ISTH: Plasma Coagulation Inhibitors, Pediatric/Neonatal Thrombosis and Hemostasis, and Women’s Health Issues in Thrombosis and Hemostasis, was developed to review the current evidence and help guide on diagnosis and management of SCPCD. We provide a summary of the clinical presentations, differential diagnoses, appropriate investigations to confirm the diagnosis, approaches for management of the acute situation, and options for long-term management including subsequent pregnancies. We finally provide a set of recommendations to help in this regard.

Originalspråkengelska
Sidor (från-till)1735-1743
Antal sidor9
TidskriftJournal of Thrombosis and Haemostasis
Volym20
Nummer7
DOI
StatusPublished - 2022 juli

Ämnesklassifikation (UKÄ)

  • Reproduktionsmedicin och gynekologi

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