Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis

Antoine Meyer; Catherine Dong; Simon S.M. Chan; Mathilde Touvier; Chantal Julia; Inge Huybrechts; Geneviève Nicolas; Bas Oldenburg; Alicia K. Heath; Tammy Y.N. Tong; Timothy J. Key; Anne Tjønneland; Cecilie Kyrø; Rudolf Kaaks; Verena A. Katzke; Manuela M. Bergman; Domenico Palli; Giovanna Masala; Rosario Tumino; Carlotta Sacerdote; Sandra M. Colorado-Yohar; Maria Jose Sánchez; Marcela Guevara; Olof Grip; Johanna Holmgren; Amanda Cross; Pontus Karling; Johan Hultdin; Neil Murphy; Mélanie Deschasaux-Tanguy; Serge Hercberg; Pilar Galan; Yahya Mahamat-Saleh; Aurélien Amiot; Marc J. Gunter; Marie Christine Boutron-Ruault; Franck Carbonnel

doi:10.1111/apt.17835

Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis

Antoine Meyer, Catherine Dong, Simon S.M. Chan, Mathilde Touvier, Chantal Julia, Inge Huybrechts, Geneviève Nicolas, Bas Oldenburg, Alicia K. Heath, Tammy Y.N. Tong, Timothy J. Key, Anne Tjønneland, Cecilie Kyrø, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta SacerdoteSandra M. Colorado-Yohar, Maria Jose Sánchez, Marcela Guevara, Olof Grip, Johanna Holmgren, Amanda Cross, Pontus Karling, Johan Hultdin, Neil Murphy, Mélanie Deschasaux-Tanguy, Serge Hercberg, Pilar Galan, Yahya Mahamat-Saleh, Aurélien Amiot, Marc J. Gunter, Marie Christine Boutron-Ruault, Franck Carbonnel

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Background: Nutri-score is now widely available in food packages in Europe. Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake. Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24–3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69–1.21; p-trend: 0.76). Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.

Originalspråk	engelska
Sidor (från-till)	558-568
Antal sidor	11
Tidskrift	Alimentary Pharmacology and Therapeutics
Volym	59
Nummer	4
Tidigt onlinedatum	2023 dec. 15
DOI	https://doi.org/10.1111/apt.17835
Status	Published - 2024 feb.
Externt publicerad	Ja

Bibliografisk information

Funding Information:
This work was supported by the Sir Halley Stewart Trust, Crohn's and Colitis UK and The UK National Health Service Executive Eastern Region. The coordination of EPIC is financially supported by the International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC).The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam‐Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro‐AIRC‐Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS) – Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology – ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC‐Norfolk; C8221/A29017 to EPIC‐Oxford), Medical Research Council (1000143 to EPIC‐Norfolk; MR/M012190/1 to EPIC‐Oxford) (United Kingdom). The funders had no role in the study design or in the collection, analysis, interpretation of data, writing of the report or decision to submit the article for publication.

Publisher Copyright:
© 2023 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.

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Meyer, A., Dong, C., Chan, S. S. M., Touvier, M., Julia, C., Huybrechts, I., Nicolas, G., Oldenburg, B., Heath, A. K., Tong, T. Y. N., Key, T. J., Tjønneland, A., Kyrø, C., Kaaks, R., Katzke, V. A., Bergman, M. M., Palli, D., Masala, G., Tumino, R., ... Carbonnel, F. (2024). Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis. Alimentary Pharmacology and Therapeutics, 59(4), 558-568. https://doi.org/10.1111/apt.17835

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title = "Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis",

abstract = "Background: Nutri-score is now widely available in food packages in Europe. Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake. Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24–3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69–1.21; p-trend: 0.76). Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.",

keywords = "dietary, EPIC, FSAm-NPS DI score, inflammatory bowel disease, nutri-score",

author = "Antoine Meyer and Catherine Dong and Chan, {Simon S.M.} and Mathilde Touvier and Chantal Julia and Inge Huybrechts and Genevi{\`e}ve Nicolas and Bas Oldenburg and Heath, {Alicia K.} and Tong, {Tammy Y.N.} and Key, {Timothy J.} and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Rudolf Kaaks and Katzke, {Verena A.} and Bergman, {Manuela M.} and Domenico Palli and Giovanna Masala and Rosario Tumino and Carlotta Sacerdote and Colorado-Yohar, {Sandra M.} and S{\'a}nchez, {Maria Jose} and Marcela Guevara and Olof Grip and Johanna Holmgren and Amanda Cross and Pontus Karling and Johan Hultdin and Neil Murphy and M{\'e}lanie Deschasaux-Tanguy and Serge Hercberg and Pilar Galan and Yahya Mahamat-Saleh and Aur{\'e}lien Amiot and Gunter, {Marc J.} and Boutron-Ruault, {Marie Christine} and Franck Carbonnel",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.",

year = "2024",

month = feb,

doi = "10.1111/apt.17835",

language = "English",

volume = "59",

pages = "558--568",

journal = "Alimentary Pharmacology and Therapeutics",

issn = "0269-2813",

publisher = "Wiley-Blackwell",

number = "4",

}

Meyer, A, Dong, C, Chan, SSM, Touvier, M, Julia, C, Huybrechts, I, Nicolas, G, Oldenburg, B, Heath, AK, Tong, TYN, Key, TJ, Tjønneland, A, Kyrø, C, Kaaks, R, Katzke, VA, Bergman, MM, Palli, D, Masala, G, Tumino, R, Sacerdote, C, Colorado-Yohar, SM, Sánchez, MJ, Guevara, M, Grip, O , Holmgren, J, Cross, A, Karling, P, Hultdin, J, Murphy, N, Deschasaux-Tanguy, M, Hercberg, S, Galan, P, Mahamat-Saleh, Y, Amiot, A, Gunter, MJ, Boutron-Ruault, MC & Carbonnel, F 2024, 'Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis', Alimentary Pharmacology and Therapeutics, vol. 59, nr. 4, s. 558-568. https://doi.org/10.1111/apt.17835

TY - JOUR

T1 - Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis

AU - Meyer, Antoine

AU - Dong, Catherine

AU - Chan, Simon S.M.

AU - Touvier, Mathilde

AU - Julia, Chantal

AU - Huybrechts, Inge

AU - Nicolas, Geneviève

AU - Oldenburg, Bas

AU - Heath, Alicia K.

AU - Tong, Tammy Y.N.

AU - Key, Timothy J.

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Kaaks, Rudolf

AU - Katzke, Verena A.

AU - Bergman, Manuela M.

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Colorado-Yohar, Sandra M.

AU - Sánchez, Maria Jose

AU - Guevara, Marcela

AU - Grip, Olof

AU - Holmgren, Johanna

AU - Cross, Amanda

AU - Karling, Pontus

AU - Hultdin, Johan

AU - Murphy, Neil

AU - Deschasaux-Tanguy, Mélanie

AU - Hercberg, Serge

AU - Galan, Pilar

AU - Mahamat-Saleh, Yahya

AU - Amiot, Aurélien

AU - Gunter, Marc J.

AU - Boutron-Ruault, Marie Christine

AU - Carbonnel, Franck

PY - 2024/2

Y1 - 2024/2

N2 - Background: Nutri-score is now widely available in food packages in Europe. Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake. Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24–3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69–1.21; p-trend: 0.76). Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.

AB - Background: Nutri-score is now widely available in food packages in Europe. Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake. Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24–3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69–1.21; p-trend: 0.76). Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.

KW - dietary

KW - EPIC

KW - FSAm-NPS DI score

KW - inflammatory bowel disease

KW - nutri-score

U2 - 10.1111/apt.17835

DO - 10.1111/apt.17835

M3 - Article

C2 - 38100159

AN - SCOPUS:85179951683

SN - 0269-2813

VL - 59

SP - 558

EP - 568

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 4

ER -

Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis

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