Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

M Obón-Santacana, R Kaaks, N Slimani, L Lujan-Barroso, H Freisling, P Ferrari, L Dossus, N Chabbert-Buffet, L Baglietto, R T Fortner, H Boeing, A Tjønneland, A Olsen, K Overvad, V Menéndez, E Molina-Montes, N Larrañaga, M-D Chirlaque, E Ardanaz, K-T KhawN Wareham, R C Travis, Y Lu, M A Merritt, A Trichopoulou, V Benetou, D Trichopoulos, C Saieva, S Sieri, R Tumino, C Sacerdote, R Galasso, H B Bueno-de-Mesquita, Elisabet Wirfält, Ulrika Ericson, A Idahl, N Ohlson, G Skeie, I T Gram, E Weiderpass, N C Onland-Moret, E Riboli, E J Duell

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

23 Citeringar (SciVal)
121 Nedladdningar (Pure)

Sammanfattning

Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.
Originalspråkengelska
Sidor (från-till)987-997
Antal sidor11
TidskriftBritish Journal of Cancer
Volym111
Nummer5
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

Fingeravtryck

Utforska forskningsämnen för ”Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här