Digital lifestyle treatment improves long-term metabolic control in type 2 diabetes with different effects in pathophysiological and genetic subgroups

Vishal A. Salunkhe, Neha Sinha, Emma Ahlqvist, Rashmi B. Prasad, Svetlana Johansson, Birgitta Abrahamsson, Anders H. Rosengren

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

To address the unmet need for scalable solutions for lifestyle treatment, we developed a new digital method to promote behavioral change. Here we report that patients with type-2 diabetes in Sweden (n = 331) exposed to the intervention have significantly improved HbA1c during a median follow-up of 1038 days (4 mmol/mol compared with matched controls; P = 0.009). This is paralleled by reduced body weight, ameliorated insulin secretion, increased physical activity, and cognitive eating restraints. Participants with high BMI and insulin resistance have an even larger response, as have non-risk allele carriers for the FTO gene. The findings open a new avenue for scalable lifestyle management with sustained efficacy and highlight a previously unrecognized opportunity for digital precision treatment based on genetics and individual pathophysiology. ClinicalTrials.gov NCT04624321.

Originalspråkengelska
Artikelnummer199
Tidskriftnpj Digital Medicine
Volym6
Nummer1
DOI
StatusPublished - 2023 dec.

Bibliografisk information

Publisher Copyright:
© 2023, The Author(s).

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes

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