Drug Repurposing in Oncology: Current Evidence and Future Direction

Zhenzhan Zhang, Jianguang Ji, Hao Liu

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.

METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based studies. The future direction of repurposed drug screening was discussed by using patient-derived tumor organoids.

RESULTS: Many old drugs showed previously unknown effects or off-target effects and can be intelligently applied for cancer chemoprevention and therapy. The identification of repurposed drugs needs to combine evidence from mechanical studies and population-based studies. Due to the heterogeneity of cancer, patient-derived tumor organoids can be used to screen the non-oncological drugs in vitro.

CONCLUSION: These identified old drugs could be repurposed in oncology and might be added as adjuvants and finally benefit patients with cancers.

Originalspråkengelska
Sidor (från-till)2175-2194
TidskriftCurrent Medicinal Chemistry
Volym28
Nummer11
DOI
StatusPublished - 2020

Ämnesklassifikation (UKÄ)

  • Läkemedelskemi
  • Farmakologi och toxikologi

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