TY - JOUR
T1 - Dynamics of the blood plasma proteome during hyperacute HIV-1 infection
AU - Nazziwa, Jamirah
AU - Freyhult, Eva
AU - Hong, Mun Gwan
AU - Johansson, Emil
AU - Årman, Filip
AU - Hare, Jonathan
AU - Gounder, Kamini
AU - Rezeli, Melinda
AU - Mohanty, Tirthankar
AU - Kjellström, Sven
AU - Kamali, Anatoli
AU - Karita, Etienne
AU - Kilembe, William
AU - Price, Matt A.
AU - Kaleebu, Pontiano
AU - Allen, Susan
AU - Hunter, Eric
AU - Ndung’u, Thumbi
AU - Gilmour, Jill
AU - Rowland-Jones, Sarah L.
AU - Sanders, Eduard
AU - Hassan, Amin S.
AU - Esbjörnsson, Joakim
PY - 2024/12
Y1 - 2024/12
N2 - The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levesls with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.
AB - The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levesls with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.
U2 - 10.1038/s41467-024-54848-0
DO - 10.1038/s41467-024-54848-0
M3 - Article
C2 - 39632834
AN - SCOPUS:85210933875
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 10593
ER -