Effect Modification between Genes and Environment and Parkinson's Disease Risk

Maria Teresa Periñán, Kajsa Brolin, Sara Bandres-Ciga, Cornelis Blauwendraat, Christine Klein, Ziv Gan-Or, Andrew Singleton, Pilar Gomez-Garre, Maria Swanberg, Pablo Mir, Alastair Noyce

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.

Originalspråkengelska
Sidor (från-till)715-724
Antal sidor10
TidskriftAnnals of Neurology
Volym92
Nummer5
Tidigt onlinedatum2022
DOI
StatusPublished - 2022 nov.

Bibliografisk information

Funding Information:
This work was supported in part by the Global Parkinson's Genetics Program (GP2). GP2 is funded by the Aligning Science Against Parkinson's (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson's Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org . This research was supported in part by the Intramural Research Program of the National Institutes of Health (National Institute on Aging, Z01‐AG000949‐02). The Preventive Neurology Unit is funded by the Barts Charity.

Publisher Copyright:
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Ämnesklassifikation (UKÄ)

  • Medicinsk genetik

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