TY - JOUR
T1 - Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system
T2 - Phase map, rheology and NMR self-diffusion study
AU - Monduzzi, Maura
AU - Musu, Giulia
AU - Grosso, Massimiliano
AU - Carucci, Cristina
AU - Lindman, Björn
AU - Söderman, Olle
AU - Salis, Andrea
PY - 2022/12
Y1 - 2022/12
N2 - This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na2SO4 > NaCl > NaSCN with more marked effect for lower concentrations. Salt addition allows to tune the crowding effect of NaCMC. For the polymer mixture and for a sample containing NaCl, 1H NMR self-diffusion experiments display a non-mono-exponential decay of the echo signals of Pluronic F127, caused by the polydispersity of commercial Pluronic F127. The rheological properties along with the diffusion behaviour of the liquid crystal micelles suggest that a sample containing NaCl 0.07 mol/kg, with a sol-hard gel transition temperature around 35 °C, close to that of the body, may be a suitable and biocompatible thermosensitive platform to administer both hydrophobic and hydrophilic drugs such as antibiotics, anticancer drugs or growing factors. Synopsis: A simple thermoresponsive platform for drug delivery: Pluronic F127, NaCMC and NaCl.
AB - This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na2SO4 > NaCl > NaSCN with more marked effect for lower concentrations. Salt addition allows to tune the crowding effect of NaCMC. For the polymer mixture and for a sample containing NaCl, 1H NMR self-diffusion experiments display a non-mono-exponential decay of the echo signals of Pluronic F127, caused by the polydispersity of commercial Pluronic F127. The rheological properties along with the diffusion behaviour of the liquid crystal micelles suggest that a sample containing NaCl 0.07 mol/kg, with a sol-hard gel transition temperature around 35 °C, close to that of the body, may be a suitable and biocompatible thermosensitive platform to administer both hydrophobic and hydrophilic drugs such as antibiotics, anticancer drugs or growing factors. Synopsis: A simple thermoresponsive platform for drug delivery: Pluronic F127, NaCMC and NaCl.
KW - Electrolytes
KW - NaCMC
KW - Pluronic F127
KW - Thermoresponsive hydrogels
U2 - 10.1016/j.eurpolymj.2022.111707
DO - 10.1016/j.eurpolymj.2022.111707
M3 - Article
AN - SCOPUS:85142140644
SN - 0014-3057
VL - 181
JO - European Polymer Journal
JF - European Polymer Journal
M1 - 111707
ER -