Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain

Per Kjellstrand; Anders Edström; M Bjerkemo; Björn Holmquist

doi:10.1016/0378-4274(82)90258-2

Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain

Per Kjellstrand, Anders Edström, M Bjerkemo, Björn Holmquist

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Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.

Originalspråk	engelska
Sidor (från-till)	1-5
Tidskrift	Toxicology Letters
Volym	10
Nummer	1
DOI	https://doi.org/10.1016/0378-4274(82)90258-2
Status	Published - 1982

Ämnesklassifikation (UKÄ)

Farmakologi och toxikologi

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10.1016/0378-4274(82)90258-2

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title = "Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain",

abstract = "Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.",

keywords = "ACPase, acid phosphatase, ANOVA, analysis of variance, CNS, central nervous system, TCE, trichloroethylene",

author = "Per Kjellstrand and Anders Edstr{\"o}m and M Bjerkemo and Bj{\"o}rn Holmquist",

year = "1982",

doi = "10.1016/0378-4274(82)90258-2",

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AU - Kjellstrand, Per

AU - Edström, Anders

AU - Bjerkemo, M

AU - Holmquist, Björn

PY - 1982

Y1 - 1982

N2 - Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.

AB - Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of ± 10–15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.

KW - ACPase

KW - acid phosphatase

KW - ANOVA

KW - analysis of variance

KW - CNS

KW - central nervous system

KW - TCE

KW - trichloroethylene

U2 - 10.1016/0378-4274(82)90258-2

DO - 10.1016/0378-4274(82)90258-2

M3 - Article

SN - 1879-3169

VL - 10

SP - 1

EP - 5

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

Effects of Trichloroethylene inhalation on acid phosphatase in rodent brain

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