Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Lucilene D. Mello; Emerson S. Ribeiro; Lauro T. Kubota; Sofi Elmroth; Regina M. S. Pereira

doi:10.1007/s10534-008-9175-2

Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Lucilene D. Mello, Emerson S. Ribeiro, Lauro T. Kubota, Sofi Elmroth, Regina M. S. Pereira

Biokemi och Strukturbiologi

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.

Originalspråk	engelska
Sidor (från-till)	385-392
Tidskrift	BioMetals
Volym	22
Utgåva	2
DOI	https://doi.org/10.1007/s10534-008-9175-2
Status	Published - 2009

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@article{43e99dcb88404e3aa770728a056f5141,

title = "Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex",

abstract = "The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.",

keywords = "Transition metal complexes, DNA, Platinum, DNA-metal complex interaction",

author = "Mello, {Lucilene D.} and Ribeiro, {Emerson S.} and Kubota, {Lauro T.} and Sofi Elmroth and Pereira, {Regina M. S.}",

year = "2009",

doi = "10.1007/s10534-008-9175-2",

language = "English",

volume = "22",

pages = "385--392",

journal = "BioMetals",

issn = "0966-0844",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

AU - Mello, Lucilene D.

AU - Ribeiro, Emerson S.

AU - Kubota, Lauro T.

AU - Elmroth, Sofi

AU - Pereira, Regina M. S.

PY - 2009

Y1 - 2009

N2 - The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.

AB - The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.

KW - Transition metal complexes

KW - DNA

KW - Platinum

KW - DNA-metal complex interaction

U2 - 10.1007/s10534-008-9175-2

DO - 10.1007/s10534-008-9175-2

M3 - Article

C2 - 18982410

VL - 22

SP - 385

EP - 392

JO - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 2

ER -

Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

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