Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Isabel Goncalves; Eva Bengtsson; Helen M Colhoun; Angela C Shore; Carlo Palombo; Andrea Natali; Andreas Edsfeldt; Pontus Dunér; Gunilla Nordin Fredrikson; Harry Björkbacka; Gerd Östling; Kunihiko Aizawa; Francesco Casanova; Margaretha Persson; Kim Gooding; David Strain; Faisel Kahn; Helen C Looker; Fiona Adams; Jill Belch; Silvia Pinnoli; Elena Venturi; Michaela Kozakova; Li-Ming Gan; Volker Schnecke; Jan Nilsson

doi:10.1161/ATVBAHA.115.305631

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Isabel Goncalves, Eva Bengtsson, Helen M Colhoun, Angela C Shore, Carlo Palombo, Andrea Natali, Andreas Edsfeldt, Pontus Dunér, Gunilla Nordin Fredrikson, Harry Björkbacka, Gerd Östling, Kunihiko Aizawa, Francesco Casanova, Margaretha Persson, Kim Gooding, David Strain, Faisel Kahn, Helen C Looker, Fiona Adams, Jill BelchSilvia Pinnoli, Elena Venturi, Michaela Kozakova, Li-Ming Gan, Volker Schnecke, Jan Nilsson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

62 Citeringar (SciVal)

Sammanfattning

Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

Originalspråk	engelska
Sidor (från-till)	1723-1731
Tidskrift	Arteriosclerosis, Thrombosis and Vascular Biology
Volym	35
Utgåva	7
DOI	https://doi.org/10.1161/ATVBAHA.115.305631
Status	Published - 2015

Ämnesklassifikation (UKÄ)

Kardiologi

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10.1161/ATVBAHA.115.305631

http://www.ncbi.nlm.nih.gov/pubmed/25953645?dopt=Abstract

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Goncalves, I., Bengtsson, E., Colhoun, H. M., Shore, A. C., Palombo, C., Natali, A., Edsfeldt, A., Dunér, P., Nordin Fredrikson, G., Björkbacka, H., Östling, G., Aizawa, K., Casanova, F., Persson, M., Gooding, K., Strain, D., Kahn, F., Looker, H. C., Adams, F., ... Nilsson, J. (2015). Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. Arteriosclerosis, Thrombosis and Vascular Biology, 35(7), 1723-1731. https://doi.org/10.1161/ATVBAHA.115.305631

Goncalves, Isabel ; Bengtsson, Eva ; Colhoun, Helen M ; Shore, Angela C ; Palombo, Carlo ; Natali, Andrea ; Edsfeldt, Andreas ; Dunér, Pontus ; Nordin Fredrikson, Gunilla ; Björkbacka, Harry ; Östling, Gerd ; Aizawa, Kunihiko ; Casanova, Francesco ; Persson, Margaretha ; Gooding, Kim ; Strain, David ; Kahn, Faisel ; Looker, Helen C ; Adams, Fiona ; Belch, Jill ; Pinnoli, Silvia ; Venturi, Elena ; Kozakova, Michaela ; Gan, Li-Ming ; Schnecke, Volker ; Nilsson, Jan. / Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. I: Arteriosclerosis, Thrombosis and Vascular Biology. 2015 ; Vol. 35, Nr. 7. s. 1723-1731.

@article{dc9b310e30f14c3e895f46f6c9d58ec2,

title = "Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.",

abstract = "Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.",

author = "Isabel Goncalves and Eva Bengtsson and Colhoun, {Helen M} and Shore, {Angela C} and Carlo Palombo and Andrea Natali and Andreas Edsfeldt and Pontus Dun{\'e}r and {Nordin Fredrikson}, Gunilla and Harry Bj{\"o}rkbacka and Gerd {\"O}stling and Kunihiko Aizawa and Francesco Casanova and Margaretha Persson and Kim Gooding and David Strain and Faisel Kahn and Looker, {Helen C} and Fiona Adams and Jill Belch and Silvia Pinnoli and Elena Venturi and Michaela Kozakova and Li-Ming Gan and Volker Schnecke and Jan Nilsson",

year = "2015",

doi = "10.1161/ATVBAHA.115.305631",

language = "English",

volume = "35",

pages = "1723--1731",

journal = "Arteriosclerosis, Thrombosis and Vascular Biology",

issn = "1524-4636",

publisher = "Lippincott Williams & Wilkins",

number = "7",

}

Goncalves, I , Bengtsson, E, Colhoun, HM, Shore, AC, Palombo, C, Natali, A, Edsfeldt, A , Dunér, P, Nordin Fredrikson, G, Björkbacka, H, Östling, G, Aizawa, K, Casanova, F, Persson, M, Gooding, K, Strain, D, Kahn, F, Looker, HC, Adams, F, Belch, J, Pinnoli, S, Venturi, E, Kozakova, M, Gan, L-M, Schnecke, V & Nilsson, J 2015, 'Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 35, nr. 7, s. 1723-1731. https://doi.org/10.1161/ATVBAHA.115.305631

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. / Goncalves, Isabel ; Bengtsson, Eva; Colhoun, Helen M; Shore, Angela C; Palombo, Carlo; Natali, Andrea; Edsfeldt, Andreas ; Dunér, Pontus; Nordin Fredrikson, Gunilla; Björkbacka, Harry; Östling, Gerd; Aizawa, Kunihiko; Casanova, Francesco; Persson, Margaretha; Gooding, Kim; Strain, David; Kahn, Faisel; Looker, Helen C; Adams, Fiona; Belch, Jill; Pinnoli, Silvia; Venturi, Elena; Kozakova, Michaela; Gan, Li-Ming; Schnecke, Volker; Nilsson, Jan.

I: Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 35, Nr. 7, 2015, s. 1723-1731.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

TY - JOUR

T1 - Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

AU - Goncalves, Isabel

AU - Bengtsson, Eva

AU - Colhoun, Helen M

AU - Shore, Angela C

AU - Palombo, Carlo

AU - Natali, Andrea

AU - Edsfeldt, Andreas

AU - Dunér, Pontus

AU - Nordin Fredrikson, Gunilla

AU - Björkbacka, Harry

AU - Östling, Gerd

AU - Aizawa, Kunihiko

AU - Casanova, Francesco

AU - Persson, Margaretha

AU - Gooding, Kim

AU - Strain, David

AU - Kahn, Faisel

AU - Looker, Helen C

AU - Adams, Fiona

AU - Belch, Jill

AU - Pinnoli, Silvia

AU - Venturi, Elena

AU - Kozakova, Michaela

AU - Gan, Li-Ming

AU - Schnecke, Volker

AU - Nilsson, Jan

PY - 2015

Y1 - 2015

N2 - Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

AB - Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

U2 - 10.1161/ATVBAHA.115.305631

DO - 10.1161/ATVBAHA.115.305631

M3 - Article

C2 - 25953645

VL - 35

SP - 1723

EP - 1731

JO - Arteriosclerosis, Thrombosis and Vascular Biology

JF - Arteriosclerosis, Thrombosis and Vascular Biology

SN - 1524-4636

IS - 7

ER -

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

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