Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

Medicin och livsvetenskap

• Crystallography 100%
• Galectins 95%
• Neutrons 92%
• Hydrogen Bonding 83%
• Lactose 81%
• Drug Design 79%
• Glycerol 72%
• Ligands 48%
• Galectin 3 39%
• Disaccharides 25%
• Binding Sites 15%
• X Ray Crystallography 13%
• Monosaccharides 12%
• Hydrogen 11%
• Molecular Dynamics Simulation 11%
• Histidine 10%
• Galactose 10%
• Carbohydrates 8%
• Glycoproteins 8%
• Water 6%
• Pharmaceutical Preparations 4%
• Proteins 3%

Kemiska föreningar

• Neutron Diffraction 72%
• Lactose 37%
• Drug 36%
• Disaccharide 35%
• Neutron 35%
• Hydrogen 34%
• Hydrogen Bond 31%
• Ligand 30%
• Binding Site 24%
• Drug Target 19%
• Histidine Residue 19%
• Crystal Structure 17%
• Glycoprotein 15%
• Hydrogen Atom 15%
• Glycerol 14%
• Carbohydrate 14%
• X-Ray Crystallography 14%
• Kd 13%
• Molecular Dynamics 12%
• Simulation 10%
• Protein 7%
• Molecule 6%