TY - JOUR
T1 - Epidemiological evidence on reproductive effects of persistent organochlorines in humans
AU - Toft, G
AU - Hagmar, L
AU - Giwercman, Aleksander
AU - Bonde, JP
PY - 2004
Y1 - 2004
N2 - Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved.
AB - Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved.
KW - endocrine disruption
KW - fertility
KW - reproduction
KW - DDE
KW - DDT
KW - organochlorines
KW - PCB
KW - human
U2 - 10.1016/j.reprotox.2004.05.006
DO - 10.1016/j.reprotox.2004.05.006
M3 - Review article
SN - 1873-1708
VL - 19
SP - 5
EP - 26
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 1
ER -