Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Gustaf Lindgren; Lars Ekblad; Johan Vallon-Christersson; Elisabeth Kjellén; Maria Gebre-Medhin; Johan Wennerberg

doi:10.1186/1471-2407-14-648

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin, Johan Wennerberg

Skåne University Hospital

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

183 Nedladdningar (Pure)

Sammanfattning

Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

Originalspråk	engelska
Artikelnummer	648
Tidskrift	BMC Cancer
Volym	14
DOI	https://doi.org/10.1186/1471-2407-14-648
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Cancer och onkologi

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.1186/1471-2407-14-648

BMC__Lindgren_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25182342?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Experimental studies on head and neck carcinoma with special reference to tumour cell response to trauma
Lindgren, G., 2021, Lund: Lund University, Faculty of Medicine. 62 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

1 Avslutade

Local recurrences in head and neck cancer – etiology and prevention
Ekblad, L. (PI), Wennerberg, J. (PI), Lindgren, G. (Forskarstuderande) & Kjellén, E. (PI)
Magnus Bergvalls Stiftelse, Fru Berta Kamprads stiftelse för utforskning och bekämpning av cancersjukdomar, Crafoordska stiftelsen
2005/01/01 → 2021/11/17
Projekt: Forskning

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title = "Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.",

abstract = "Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.",

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language = "English",

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journal = "BMC Cancer",

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T1 - Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

AU - Lindgren, Gustaf

AU - Ekblad, Lars

AU - Vallon-Christersson, Johan

AU - Kjellén, Elisabeth

AU - Gebre-Medhin, Maria

AU - Wennerberg, Johan

PY - 2014

Y1 - 2014

N2 - Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

AB - Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

U2 - 10.1186/1471-2407-14-648

DO - 10.1186/1471-2407-14-648

M3 - Article

SN - 1471-2407

VL - 14

JO - BMC Cancer

JF - BMC Cancer

M1 - 648

ER -

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

Fingeravtryck

Forskningsoutput

Experimental studies on head and neck carcinoma with special reference to tumour cell response to trauma

Projekt

Local recurrences in head and neck cancer – etiology and prevention

Citera det här