TY - JOUR
T1 - European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)
AU - Düzel, Emrah
AU - Acosta-Cabronero, Julio
AU - Berron, David
AU - Biessels, Geert Jan
AU - Björkman-Burtscher, Isabella
AU - Bottlaender, Michel
AU - Bowtell, Richard
AU - Buchem, Mark v.
AU - Cardenas-Blanco, Arturo
AU - Boumezbeur, Fawzi
AU - Chan, Dennis
AU - Clare, Stuart
AU - Costagli, Mauro
AU - de Rochefort, Ludovic
AU - Fillmer, Ariane
AU - Gowland, Penny
AU - Hansson, Oskar
AU - Hendrikse, Jeroen
AU - Kraff, Oliver
AU - Ladd, Mark E.
AU - Ronen, Itamar
AU - Petersen, Esben
AU - Rowe, James B.
AU - Siebner, Hartwig
AU - Stoecker, Tony
AU - Straub, Sina
AU - Tosetti, Michela
AU - Uludag, Kamil
AU - Vignaud, Alexandre
AU - Zwanenburg, Jaco
AU - Speck, Oliver
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.
AB - Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.
KW - Alzheimer's disease (AD)
KW - Magnetic resonance imaging (MRI)
KW - Mild cognitive impairment (MCI)
KW - Parkinson's disease (PD)
KW - Subjective cognitive decline (SCD)
KW - Ultrahigh-field MRI
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=85069944986&partnerID=8YFLogxK
U2 - 10.1016/j.dadm.2019.04.010
DO - 10.1016/j.dadm.2019.04.010
M3 - Article
C2 - 31388558
AN - SCOPUS:85069944986
SN - 2352-8729
VL - 11
SP - 538
EP - 549
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -